It happened at around 6.30pm on Friday (19th December). Officers were called to reports of a collision on Porth Way, at the junction with Well Way.
It involved a white Volkswagen Golf and an electric bike.
The rider of the bike, a man in his 20s from the Newquay area, sustained serious injuries and was taken to hospital for treatment. His next of kin have been informed.
Local road closures were put in place while officers conducted an examination of the scene. The road was reopened at around 10.30pm.
A spokesperson for Devon and Cornwall Police said: "If you witnessed the incident or have any information or dash cam footage that could help with enquiries, please contact us via our website or by calling 101 quoting log 670 of 19/12/25."
UK Surf & Skate Expo to return with bigger line-up in Newquay
Methodist minister reflects on eight years in Newquay as she prepares to move on
Concerns raised over anti-social behaviour near Newquay's new play park
Police appeal after 64 sheep stolen near Halloon Roundabout
Council backs replacing South West Water with a publicly owned company
Two men killed in collision near the A30
Poundstretcher confirms opening date for new Newquay store
Skybus customers contacted over Newquay flight changes
Newquay RNLI crew rescue man and dog from harbour in early morning call-out
Van occupants ordered to leave Newquay car park by Friday afternoon
English Para Surfing Open attracts competitors from across the UK and Europe to Fistral
One person taken to hospital after crash closes Newquay road
Boardmasters outlines welfare and safeguarding measures ahead of festival
Newquay mayor backs launch of Beryl e-scooters in town
Cornwall's worst mining disaster to be commemorated
Newquay BID launches campaign to encourage visitors during Boardmasters week