Construction will begin on a Tesco store on the estate's Market Street early next year.
A spokesperson for the Duchy of Cornwall said Market Street will also contain independent shops, cafes and restaurants.
It's expected around 100 jobs will be created by the new Tesco store - and will have a footprint of 2,283sq m.
Sam Kirkness, Nansledan Development Manager at the Duchy of Cornwall, said: “We’re delighted to have secured Tesco as part of Market Street’s exciting and diverse retail offer and are hugely encouraged by the number of direct approaches so far from local established businesses, independents and start-ups, all interested in becoming part of a modern-day high street and lifestyle destination for North Cornwall.”
Two people die after being recovered from the sea at South Fistral
UK Surf & Skate Expo to return with bigger line-up in Newquay
Methodist minister reflects on eight years in Newquay as she prepares to move on
Concerns raised over anti-social behaviour near Newquay's new play park
Police appeal after 64 sheep stolen near Halloon Roundabout
Council backs replacing South West Water with a publicly owned company
Two men killed in collision near the A30
Poundstretcher confirms opening date for new Newquay store
Skybus customers contacted over Newquay flight changes
Newquay RNLI crew rescue man and dog from harbour in early morning call-out
Van occupants ordered to leave Newquay car park by Friday afternoon
English Para Surfing Open attracts competitors from across the UK and Europe to Fistral
One person taken to hospital after crash closes Newquay road
Boardmasters outlines welfare and safeguarding measures ahead of festival
Newquay mayor backs launch of Beryl e-scooters in town
Cornwall's worst mining disaster to be commemorated
Newquay BID launches campaign to encourage visitors during Boardmasters week